Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG3340 | non-peptidomimetric hydroxamate matrix metalloproteinase inhibitor, IC50: 120 nM | Bos taurus | |
alpha2-Macroglobulin | - |
Bos taurus | |
BB-16 | peptidomimetric hydroxamate, synthetic inhibitor originally targeted for matrix metalloproteinases, IC50: 150 nM | Bos taurus | |
chondroitin 6-sulfate | - |
Bos taurus | |
dermatan sulfate | - |
Bos taurus | |
DPC | non-peptidomimetric hydroxamate matrix metalloproteinase inhibitor, IC50: 10 nM | Bos taurus | |
enoxaparin | - |
Bos taurus | |
fibronectin | IC50: 110 nM | Bos taurus | |
heparan sulfate | - |
Bos taurus | |
heparin | - |
Bos taurus | |
Keratan sulfate | - |
Bos taurus | |
marimastat | IC50: 210 nM | Bos taurus | |
SE206 | macrocyclic derivate of BB-16, IC50: 76 nM | Bos taurus | |
tinzaparin | - |
Bos taurus | |
tissue inhibitor of matrix metalloproteinases-3 | TIMP-3 | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Macro S strong cation exchange and gelatin-agarose affinity column chromatography | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | - |
Bos taurus | fragments of aggrecan | - |
? | |
N-procollagen + H2O | - |
Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aggrecanase-1 | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000033 | - |
tissue inhibitor of matrix metalloproteinases-3 | - |
Bos taurus | |
0.00002 | - |
tinzaparin | - |
Bos taurus | |
0.00008 | - |
enoxaparin | - |
Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
non-peptidomimetric hydroxamate matrix metalloproteinase inhibitor, IC50: 10 nM | Bos taurus | DPC | |
0.000076 | - |
macrocyclic derivate of BB-16, IC50: 76 nM | Bos taurus | SE206 | |
0.00011 | - |
IC50: 110 nM | Bos taurus | fibronectin | |
0.00012 | - |
non-peptidomimetric hydroxamate matrix metalloproteinase inhibitor, IC50: 120 nM | Bos taurus | AG3340 | |
0.00015 | - |
peptidomimetric hydroxamate, synthetic inhibitor originally targeted for matrix metalloproteinases, IC50: 150 nM | Bos taurus | BB-16 | |
0.00021 | - |
IC50: 210 nM | Bos taurus | marimastat |